In the town of Malaria, anatomy is destiny. Boy babies get their assignments at birth. Those without hunchbacks become evil scientists. Those with hunchbacks become Igors and spend their days saying, “Yes, master,” when ordered to “Throw the switch!”

Malaria was once a happy farming community. But some sort of climate change resulted in constant thunderstorms and now the entire economy depends on evil inventions and the biggest event of the year is the annual evil science fair competition. But not all of the people in Malaria are right for their assigned roles. Dr. Glickenstein (voice of John Cleese) is not a very good evil scientist. His Igor (John Cusack) has the hunchback of an assistant but the heart of an inventor. And the most evil scientist of all, Dr. Schadenfreude (voice of Eddie Izzard) cannot invent anything at all and relies on tricks and spying to steal the inventions of others. Igor, with the help of two assistants he invented, the immortal cat-like Scamper (voice of Steve Buscemi) and a brain in a jar named Brain (voice of Sean Hayes), invents a bride-of-Frankensteinish monster (voice of Molly Shannon). But she, too, turns out not to fit into the role she has been assigned.

The tone of the movie is cheerily macabre, so parents should be cautious about allowing young or especially sensitive children to see it. But for those who are able to be in on the joke, the film has a number of delights, from the Louis Prima songs on the soundtrack to the tweaks and jibes at horror films, “Annie,” and James Lipton’s “Inside the Actor’s Studio.”